Genica Next Generation Tests for Allergies
Allergies and Intolerances

Next Generation Tests for Allergies

Allergies occur when your immune system reacts to a foreign substance — such as pollen, bee venom or pet dander — or a food that doesn't cause a reaction in most people.

Your immune system produces substances known as antibodies. When you have allergies, your immune system makes antibodies that identify a particular allergen as harmful, even though it isn't. When you come into contact with the allergen, your immune system's reaction can inflame your skin, sinuses, airways or digestive system.

The severity of allergies varies from person to person and can range from minor irritation to anaphylaxis — a potentially life-threatening emergency. While most allergies can't be cured, treatments can help relieve your allergy symptoms.

Blood tests for allergies measure the quantity of antibodies that cause allergies, known as antibodies to immunoglobulin E (IgE). 

New Generation Allergy Test

Food Allergy Test Panel 1 (20 allergens)

Allergy tests are used to detect if the blood contains antibodies to a particular substance, such as peanuts or pollen, for example. These antibodies are called immunoglobulin E or IgE antibodies. If a person's blood contains IgE antibodies, specific to a particular substance, it means that he/she is allergic to that substance. These antibodies cause rashes, itching, sneezing and other symptoms.

Diagnostic Range: The following allergens were tested: egg white, egg yolk, cow's milk, bread yeast, wheat flour, rye flour, rice, soy, peanuts, hazelnuts, almonds, apple, kiwi, peach, tomato, carrot, potato, celery, cod , sea crab (chicken).

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 110

Clinical application

 Urticaria; Eczema; Anaphylaxis; Asthma; Allergic rhinitis; Atopic dermatitis. 

New Generation Allergy Tests

Food Panel 2 (35 allergens)

Allergy tests are used to detect if the blood contains antibodies to a particular substance, such as peanuts or pollen, for example. These antibodies are called immunoglobulin E or IgE antibodies.

If a person's blood contains IgE antibodies, specific to a particular substance, it means that he/she is allergic to that substance. These antibodies cause rashes, itching, sneezing and other symptoms. 

Diagnostic Range: The following allergens are tested: egg white, egg yolk, cow's milk, cow's milk (pasteurized), casein, wheat flour, gluten, rice, soy, sesame, peanut, hazelnut, pistachio, sunflower seed, pumpkin seed, cocoa, orange, strawberry, apple, banana, kiwi, mulberry, fig, tomato, carrot, potato, onion, peach, cherry, olive, green beans, mix fish 1 (cod, herring, mackerel, flounder), mix seafood (lobster, oyster, thick shelled river mussel), mixed meat 2 (beef, lamb), chicken.

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 150

Clinical application

Urticaria; Eczema; Anaphylaxis; Asthma; Allergic rhinitis; Atopic dermatitis 

New Generation Allergy Tests

Inhalant Allergy Panel

Allergy tests are used to detect if the blood contains antibodies to a particular substance, such as peanuts or pollen, for example. These antibodies are called immunoglobulin E or IgE antibodies. 

If a person's blood contains IgE antibodies, specific to a particular substance, it means that he/she is allergic to that substance. These antibodies cause rashes, itching, sneezing and other symptoms. 

Diagnostic Range: The following allergens are tested: common odor, hedgehog, meadow timothy, cultivated rye, alder, birch, hazelnut, oak, ragweed, wild wormwood, plantain, house dust mites (Dermatoph.pt.), House dust mites. far.), cat, dog, horse, mold (Penicillium not.), mold (Cladosporium her.), mold (Aspergillus fum.), mold (Alternaria alt.).

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 110

Clinical application

Urticaria; Eczema; Anaphylaxis; Asthma; Allergic rhinitis; Atopic dermatitis

New Generation Allergy Tests

Inhalant Allergy Panel (29 allergens)

Allergy tests are used to detect if the blood contains antibodies to a particular substance, such as peanuts or pollen, for example. These antibodies are called immunoglobulin E or IgE antibodies. 

If a person's blood contains IgE antibodies, specific to a particular substance, it means that he/she is allergic to that substance. These antibodies cause rashes, itching, sneezing and other symptoms. 

Diagnostic Range: The following allergens are tested: sweet vernal grass, сat grass, timothy grass, cob, common reed, Yorkshire fog, cultivated rye, cultivated oats, cultivated barley, cultivated wheat, alder, birch, hazel, European ash, cypress, oak, olive tree, white mulberry, hyacinth, tulip, rose, chrysanthemum, ragweed, salsola ruthenica, rough cocklebur, salsify, nettle, mugwort, ribwort plantain, red-root amaranth, parietaria, house dust mites (Dermatoph. .), house dust mites (Dermatoph.far.), cockroach (German cockroach), chicken feathers, duck feathers, goose feathers, budgerigar feathers, canary feathers, parrot feathers, small parrot feathers , zebra finch feathers, cat, dog, horse, cow, goat, sheep, hamster, Candida albicans, Rhizopus nigricans, Aureobasidium pullulans, Penicillium viridicatum, Bipolaris spicifera, molds (Penicillium not.), molds (Cladosporium her. (Aspergillus fum.), molds (Al ternaria alt.).

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 160

Clinical application

Urticaria; Eczema; Anaphylaxis; Asthma; Allergic rhinitis; Atopic dermatitis

New Generation Allergy Tests

Pediatric Panel 1 (27 allergens)

Allergy tests are used to detect if the blood contains antibodies to a particular substance, such as peanuts or pollen, for example. These antibodies are called immunoglobulin E or IgE antibodies. 

If a person's blood contains IgE antibodies, specific to a particular substance, it means that he/she is allergic to that substance. These antibodies cause rashes, itching, sneezing and other symptoms.

Diagnostic Range: The following allergens are tested: grass mix, birch, mugwort, house dust mites (Dermatoph.pt.), house dust mites (Dermatoph.far.), cat, dog, horse, mold (Cladosporium her.), mold Aspergillus fum.), molds (Alternaria alt.), egg white, egg yolk, cow's milk, cod, α-lactalbumin, β-lactoglobulin, casein, bovine serum albumin-BSA, wheat flour, rice, soy, peanuts, hazelnuts , carrot, potato, apple.

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 110

Clinical application

Urticaria; Eczema; Anaphylaxis; Asthma; Allergic rhinitis; Atopic dermatitis

New Generation Allergy Tests

Pediatric Panel 2 (54 allergens)

Allergy tests are used to detect if the blood contains antibodies to a particular substance, such as peanuts or pollen, for example. These antibodies are called immunoglobulin E or IgE antibodies. 

If a person's blood contains IgE antibodies, specific to a particular substance, it means that he/she is allergic to that substance. These antibodies cause rashes, itching, sneezing and other symptoms.

Diagnostic Range: The following allergens are tested: house dust mites (Dermatoph.pt.), House dust mites (Dermatoph.far.), bee stings, wasp stings, cockroaches (German cockroach), house dust mix, cat, dog, horse, mold (Penicillium not.), mold (Cladosporium her.), mold (Aspergillus fum.), mold (Alternaria alt.), sweet vernal grass, cat grass, timothy grass, cultivated rye, alder, birch, hazelnut tree, oak , cypress, ragweed, mugwort, Plantago, latex, tomato, carrot, potato, celery, egg white, egg yolk, cow's milk, cod, sea crab (chicken), shrimp, beef serum albumin - BSA, α-lactalbumin, β-lactoglobulin, casein, beef, lamb (sheep), yeast, wheat flour, rye flour, rice, soy, sesame, peanuts, hazelnuts, almonds, apple, kiwi, apricot.

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 170

Clinical application

Urticaria; Eczema; Anaphylaxis; Asthma; Allergic rhinitis; Atopic dermatitis

Allergy Tests

ALEX 2 (Allergy Explorer, 282 allergens)

The ALEX test is the first multiplex in vitro allergy test, allowing the simultaneous determination of total IgE (tIgE) and specific IgE (sIgE) against multiple allergen extracts and molecular allergens. It includes a total of 282 tests covering 167 different natural allergens (more than 150 allergen extracts and over 100 molecular allergens - pollen, mold, fungi associated with atopic dermatitis and other skin diseases - mites, pets, insects and many foods), supplemented with total IgE.

The test can cover over 99% of the allergens needed for routine diagnosis.

Diagnostic Range: The full list of allergens tested can be seen here (See more)

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 5-7 business days

Fee: BGN 340

Clinical application

Urticaria; Eczema; Anaphylaxis; Asthma; Allergic rhinitis; Atopic dermatitis

Download a Sample of Report

New Generation Allergy Tests

Allergic Reactions to Antibiotics

Allergy tests are used to detect if the blood contains antibodies to a particular substance, such as peanuts or pollen, for example. These antibodies are called immunoglobulin E or IgE antibodies. If a person's blood contains IgE antibodies, specific to a particular substance, it means that he/she is allergic to that substance. These antibodies cause rashes, itching, sneezing and other symptoms.

Diagnostic Range: The following allergens are tested: Penicillin G, Penicillin V, Ampicillin, Amoxicillin, Sulfamethoxazole, Cephalosporin, Ofloxacin, Cefaclor, Tetracycline, Erythromycin

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 125

Clinical application

Urticaria; Eczema; Anaphylaxis; Asthma; Allergic rhinitis; Atopic dermatitis

Food Intolerance Tests

Food Intolerances 24

Unlike classic allergies, where IgE antibodies are formed for rapid allergy, food intolerances produce IgG antibodies, that cause a delayed type of reaction. The condition is also called "food hypersensitivity". 

When that happens, specific IgG antibodies are formed, and they accept certain dietary proteins as foreign antigens. The result is a delayed immune response - within a few days. 

To see the tests types we offer, please click HERE.

Diagnostic Range: The following allergens are tested: egg white, egg yolk, cow's milk, yeast, wheat flour, rye flour, rice, soy, peanuts, hazelnuts, almonds, apple, kiwi, peach, tomato, carrot, potato, celery, cod, sea crab (chicken).

Diagnostic Method: ELISA

Research Material: 1-4 ml venous / capillary blood in a serum tube

Deadline for analysis: 5 business days

Fee: BGN 190

Clinical application

Urticaria; Dermatitis; Acne; Itching; Asthma; Persistent cough; Constant hunger; Swelling of the abdomen; Intestinal rumbling; Constipation or diarrhea; Headache; Migraine; Sleep disorders; Fatigue

Food Intolerance Tests

Food Intolerances 108

Unlike classic allergies, where IgE antibodies are formed for rapid allergy, food intolerances produce IgG antibodies, that cause a delayed type of reaction. The condition is also called "food hypersensitivity". 

When that happens, specific IgG antibodies are formed, and they accept certain dietary proteins as foreign antigens. The result is a delayed immune response - within a few days. 

Diagnostic Range: The following foods are tested: barley, cherry, gluten, grapes (white / black), oats, kiwi, rye, lemon, spelt, nectarine, wheat, orange, buckwheat, pineapple, flaxseed, strawberries, corn, watermelon, millet, pear, rice, plum, beef, grapefruit, chicken, peach, mutton, date palm, pork, basil, turkey, pepper (black / white), cow's milk, cinnamon, egg yolk, garlic, egg protein, mustard seeds, goat cheese, nutmeg, goat milk, oregano, sheep cheese, parsley, sheep milk, peppermint, yogurt, poppy seeds, eggplant, rosemary, beets, thyme, bell pepper, vanilla, broccoli, almonds, carrots, cashews, celery, cocoa beans, chili, hazelnuts, cucumber, peanuts, horseradish, pistachios, leeks, sesame seeds, olives, sunflower seeds, onions, walnuts, potatoes, coconut, red cabbage, mixed mushrooms 1 (oyster mushroom, white mushroom, shiitake, boletus), tomato, mixed mushrooms 2 (bay bolete, Boletus edulis), turnip, freshwater crab, green zucchini, salmon, artichoke, tuna, asparagus, clam, spinach, large shrimp, green beans, anchovies, peas, swordfish, soybeans, trout, lentils, sole, beans, cod, lettuce, brewer's yeast, corn salad, baker's yeast, apple, honey, apricot, coffee, banana, black tea.

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 520

Clinical application

Urticaria; Dermatitis; Acne; Itching; Asthma; Persistent cough; Constant hunger; Swelling of the abdomen; Intestinal rumbling; Constipation or diarrhea; Headache; Migraine; Sleep disorders; Fatigue

Food Intolerance Tests

Food Intolerances 216

Unlike classic allergies, where IgE antibodies are formed for rapid allergy, food intolerances produce IgG antibodies, that cause a delayed type of reaction. The condition is also called "food hypersensitivity". 

When that happens, specific IgG antibodies are formed, and they accept certain dietary proteins as foreign antigens. The result is a delayed immune response - within a few days.

Diagnostic Range: The following foods are tested: barley, cherry, locust bean, lime, gluten, grapes (white / black), rapeseed, lychee, oats, kiwi, duck meat, mango, rye, lemon, goat meat, papaya, spelt, nectarine, goose meat, pomegranate, wheat, orange, ostrich meat, raspberry, buckwheat, pineapple, quail meat, rose hips, flaxseed, strawberries, rabbit meat, melon, corn, watermelon, venison, raisins, millet, pear, guinea fowl, anise, rice, plum, horse meat, bay leaf, beef, grapefruit, kefir, chamomile, chicken, peach, beta lactoglobulin, capers, sheep meat, date palm (date), butter, chives, pork, basil, camembert, cloves, turkey meat, pepper (black / white), casein, coriander, cow's milk, cinnamon, Emmental, cumin, egg yolk, garlic, cottage cheese, dill, egg white, mustard seeds, mozzarella , ginger, goat cheese, nutmeg, processed cheese, oregano, goat milk, cottage cheese (Kurdish type), saffron, sheep cheese, parsley, bamboo stalks, sage, sheep milk, peppermint, brussels sprouts, hot red pepper, yogurt, poppy seeds, cauliflower, curry, eggplant, rosemary, spinach / beetroot, tarragon, beets, thyme, Chinese cabbage, hops, bell pepper, vanilla, dill, mint, broccoli , almond, pumpkin, Brazil nut, carrot, cashew, Jerusalem artichoke, macadamia, celery, cocoa, beans, kale, cedar nuts, chili, hazelnut, radish, chestnut, cucumber, peanut, savoy cabbage, African kola tree fruit, horseradish, pistachio, sweet potato, carp, leek, sesame, vine, squid, olive, sunflower seed, white cabbage, eel, onion, walnut, shallot (onion), bream, potato, coconut, licorice (licorice root), sea bass, red cabbage, mixed mushrooms 1 (oyster mushroom, white mushroom, shiitake, boletus), tomato, mixed mushrooms 2 (bay bolete , Boletus edulis), broad beans, turbot, turnip, freshwater crab, chickpeas, herring, zucchini, salmon, mung beans, lobster, artichoke, tuna, white beans, mackerel, asparagus, mussels, chicory, octopus, spinach, shrimp, iceberg, oyster, green beans, anchovies, arugula, sardines, peas, swordfish, avocado, ocean perch, soybeans, blackberry, sea bass, lentils, sole, blueberry, caviar, beans, cod fish, cranberry, sea crab, lettuce, brewer's yeast, red currants, agar-agar, corn salad, baker's yeast, black currants, aloe vera, apple, honey, fig, green tea, apricot, coffee, gooseberries , baking powder, banana, black tea, melon (honeydew), saffron oil.

Diagnostic Method: Enzyme Allergo-Sorbent Testing

Research Material: 1-4 ml venous / capillary blood in a serum tube

Results within: 3-5 business days

Fee: BGN 690

Clinical application

Urticaria; Dermatitis; Acne; Itching; Asthma; Persistent cough; Constant hunger; Swelling of the abdomen; Intestinal rumbling; Constipation or diarrhea; Headache; Migraine; Sleep disorders; Fatigue 

Impaired Histamine Degradation

Histamine Intolerance

A wide range of foods are naturally rich in histamine or release high levels of histamine during storage. Diamine oxidase (DAO) is an intestinal enzyme that normally destroys histamine contained in food. Therefore, even after consuming foods rich in histamine, no symptoms are observed. In carriers of genetic variants, DAO deficiency is observed, and undigested histamine is unnecessarily absorbed, exhibiting various symptoms.

Gastrointestinal symptoms: diarrhea, irritable bowel syndrome (IBS), chronic constipation, gas, stomach pain, vomiting.

Symptoms affecting the head and face: redness of the face and / or chest (a very common symptom), migraine-like headache, Quincke's edema (swelling that occurs mainly around the eyes and lips, sometimes in the throat).

Respiratory problems: asthma, stuffy nose and watery eyes.

Skin complaints: rash, eczema, urticaria, acne.

In women: dysmenorrhea. The symptoms of HIT disappear during pregnancy and return after birth.

Other symptoms: wheezing, sleep disorders, arrhythmia, mood swings - from fatigue to irritability and aggression.

Diagnostic Range: DAO; HNMT

Diagnostic Method: Sanger sequencing

Research Material: 3-6 ml venous blood / 2 ml peripheral blood

Results within: 10 business days

Fee: BGN 200

Clinical application

Histamine intolerance

Genetic Test for Mutations Causing Impaired Fructose Metabolism

Fructose Intolerance

Hereditary fructose intolerance (HFI) is an autosomal recessive disorder where fructose metabolism is impaired. It results from a deficiency of the enzyme aldolase B. HFI is caused by mutations in the ALDOB gene (9q22.3) resulting in reduced enzyme function. Affected individuals are asymptomatic until they start taking fructose, sucrose, or sorbitol.

HFI should not be confused with a condition called fructose malabsorption. In it, the intestinal cells cannot normally absorb fructose, which leads to bloating, diarrhea or constipation, flatulence, and abdominal pain.

The test is needed if fructose intolerance is suspected. Genetic analysis makes it possible to avoid invasive liver biopsy by detecting at-risk patients carrying a specific mutation.

Diagnostic Range: ALDO B

Diagnostic Method: Sanger sequencing

Research Material: 3-6 ml venous blood / 2 ml peripheral blood

Results within: 10 business days

Fee: BGN 450

Clinical application

Fructose intolerance; Food intolerance

Non-Invasive Genetic Testing for Celiac Disease

Gluten Intolerance (Celiac Disease)

Celiac disease is an autoimmune disease occurring in genetically predisposed people of different ages. It is due to intolerance to gluten and other similar proteins contained in wheat, rye, oats and barley. As a result, chronic inflammation, atrophy of the villis and thinning of the lining of the small intestine occur.

In patients with a predisposition to celiac disease (high and medium risk), it may be triggered by surgery, pregnancy, viral infections (with rota- and adenoviruses), stressful situations, etc.

The test is prescribed when celiac disease is suspected and positive immunological markers for this disease exist. Genetic analysis makes it possible to detect patients at risk without performing an invasive small bowel biopsy.

Diagnostic Range: Allelic groups HLA-DQB1 * 02, DQB1 * 03: 02 and DQA1 * 05

Diagnostic Method: PCR

Research Material: 3-6 ml venous blood / 2 ml peripheral blood

Results within: 10 business days

Fee: BGN 260

Clinical application

Gluten intolerance; Food intolerance

Consumption of Dairy Products

Lactose Intolerance

The test is an analysis of a genetic variant affecting the production of the enzyme lactase, encoded by the LCT gene. This enzyme is responsible for the lactose breakdown and its reduced function leads to impaired breakdown and absorption of the lactose in milk. The increased risk of lowered lactase function leads to a risk of developing lactose intolerance and the need to reduce the intake of milk and dairy products.

Diagnostic Range: Lactose absorption

Diagnostic Method: Sanger sequencing

Research Material: 3-6 ml venous blood / 2 ml peripheral blood

Results within: 10 business days

Fee: BGN 100

Clinical application

Lactose intolerance

Metabolism of Histamine

DAO Activity

Diamine oxidase is an important endogenous enzyme responsible for the metabolism of histamine in the body. Diamine oxidase is found mainly in the small intestine, liver, kidneys, and blood granulocytes. The activity of the DAO enzyme regulates the rate of histamine metabolism. Its measurement can be associated with histamine intolerance. In case of DAO deficiency or inhibition of its activity, histamine is not metabolized normally.

Diagnostic Range: Quantitative determination of diamine oxidase activity

Diagnostic Method: ELISA

Research Material: 2 ml of serum

Results within: 15-20 business days

Fee: BGN 84

Clinical application

Gastrointestinal disorders; Histamine intolerance; Allergies.

Quantification of Histamine and Zonulin

Intestinal Permeability

The panel includes quantification of histamine and zonulin, which at high values can cause intestinal permeability. This can lead to inflammatory bowel disorders and autoimmune diseases, food intolerances, infections, reduced colonization, and other eating disorders.

Diagnostic Range: Histamine; Zonulin

Diagnostic Method: ELISA

Research Material: Feces

Results within: 15-20 business days

Fee: BGN 168

Clinical application

Crohn's disease; Ulcerative colitis; Allergies; Food intolerances; Type 1 diabetes; Multiple sclerosis; Rheumatoid arthritis; Mental disorders; Celiac disease